Respiratorne infekcije uzrokovane klamidijom trahomatis u novorođenčadi i dojenčadi

Autor: A. Baće, M. Perović, M. Balen-Topić, L. Markovinović
Jazyk: chorvatština
Rok vydání: 2006
Předmět:
Zdroj: Infektološki glasnik
Volume 26
Issue 3
ISSN: 1848-7769
1331-2820
Popis: Retrospektivno smo analizirali klinička, dijagnostička i terapijska obilježja infekcije uzrokovane C. trachomatis u 46 bolesnika novorođenačke i dojenačke dobi, koji su bili hospitalizirani u Klinici za infektivne bolesti od prosinca 1994. do listopada 2005. Prosječna starost kod razbolijevanja bila je sedam tjedana. U 44/46 (95,6 %) djece infekcija je dokazana metodom DNA-RNAhibridizacije, a u preostalih izolacijom na staničnoj kulturi (McCoy). Uzročnik je najčešće dokazan iz aspirata nazofarinksa. U 16/46 (34,8 %) djece dokazana je monoinfekcija klamidijom trahomatis, a u ostalih koinfekcija, najčešće s respiratornim sincicijskim virusom (RSV). Većinom su djeca pri prijamu bila febrilna i imala su simptome respiratornog katara: suhi kašalj, sekreciju iz nosa te injekciju konjunktiva. Petero djece je zbog teškog općeg stanja strojno ventilirano. S obzirom na laboratorijska obilježja, 4/16 (25,0 %) djece s monoinfekcijom imalo je eozinofiliju, a 13/16 (81,3 %) hipergamaglobulinemiju. 27/46 (58,7 %) djece je liječeno azitromicinom, a 19/46 (41,3 %) eritromicinom. Trajanje hospitalizacije u djece liječene azitromicinom je bilo 13,9 dana, a u djece liječene eritromicinom 22,6 dana. Sva su djeca izliječena.
We retrospectively analyzed clinical, diagnostic and therapeutic characteristics of Chlamyda trachomatis infection in 46 newborns and infants hospitalized at the University Hospital for Infectious Diseases Zagreb between December 1994 and October 2005. The median age of patients was seven weeks. In 44/46 (95.6 %) children Chlamydia was demonstrated by using the DNA-RNA hybridisation method, and in the remaining by cell culture (McCoy). Chlamydia was mostly isolated from a nasal aspirate. Altogether 16/46 (34.7 %) children had Chlamyda trachomatis monoinfection and the rest had a co-infection, mostly with RSV. On admission, the majority of children were febrile and had the following respiratory symptoms: dry cough, nasal secretion and conjunctival infection. Because of poor general condition, five patients were mechanically ventilated. Concerning laboratory characteristics, 4/16 (25.0 %) children with monoinfection had eosinophilia, and 13/16 (81.3 %) hypergammaglobulinaemia. In total, 27/46 (58.7 %) children were treated with azithromycin, and 19/46 (41.3 %) with erythromycin. The children treated with azithromycin were hospitalized for 13.9 days, and the children treated with erythromycin for 22.6 days. All children recovered successfully.
Databáze: OpenAIRE
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