Formulation development of oral controlled release tablets of hydralazine: Optimization of drug release and bioadhesive characteristics
| Autor: | BHUPINDER SINGH, SONIA PAHUJA, RISHI KAPIL, NAVEEN AHUJA |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Acta Pharmaceutica Volume 59 Issue 1 |
| ISSN: | 1846-9558 1330-0075 |
| Popis: | The current study involves development of oral bioadhesive hydrophilic matrices of hydralazine hydrochloride, and optimization of their in vitro drug release profile and ex vivo bioadhesion against porcine gastric mucosa. A 32 central composite design was employed to systematically optimize the drug delivery formulations containing two polymers, viz., carbomer and hydroxypropyl methyl cellulose. Response surface plots were drawn and optimum formulations were selected by brute force searches. Validation of the formulation optimization study indicated a very high degree of prognostic ability. The study successfully undertook the development of an optimized once-a-day formulation of hydralazine with excellent bioadhesive and controlled release characteristics. Istraživanje uključuje razvoj bioadhezivnih hidrofilnih matriksa hidralazin hidroklorida za oralnu uporabu, optimizaciju oslobađanja ljekovite tvari in vitro i bioadhezivnih svojstava ex vivo na sluznici želuca svinje. 32 dizajniranje korišteno je za sistematsko optimiranje formulacija koje u sastavu imaju dva polimera, karbomer i hidroksipropilmetilcelulozu. Nacrtane su krivulje ovisnosti i grubo odabrane optimalne formulacije. Validacija optimiranih formulacija ukazuje vrlo visoki stupanj predvidljivosti. Razvijena je optimirana formulacija hidralazina koja se dozira jednom dnevno, a ima izvrsnu bioadhezivnost i sposobnosti kontroliranog oslobađanja. |
| Databáze: | OpenAIRE |
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