Adjunctive treatment of leptospirosis with corticosteroids: a case report

Autor: Božana Miklaušić Pavić
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Infektološki glasnik
Volume 39
Issue 2
ISSN: 1848-7769
1331-2820
Popis: Leptospiroza je jedna od globalno najraširenijih zoonoza, uzrokovana patogenim spiralnim bakterijama iz roda Leptospira spp. Ikterična leptospiroza je teški oblik bolesti koji se javlja kod 5-15 % bolesnika i često ima brzu progresiju i visoku smrtnost. Pravovremena sumnja i dokaz leptospiroze ključni su za početak adekvatne terapije kako bi se spriječio razvoj teškog oblika bolesti i smanjila smrtnost. U dostupnoj literaturi sve je više dokaza kako rana primjena kortikosteroida kod teških kliničkih oblika utječe na tijek bolesti, sprječava razvoj multiorganskog zatajenja organa, smanjuje smrtnost i skraćuje vrijeme hospitalizacije. Ovo je prikaz bolesnika s teškom ikteričnom leptospirozom koji je liječen antimikrobnom i kortikosteroidnom terapijom. Bolesnik se u potpunosti oporavio bez zaostalih posljedica teške bolesti.
Leptospirosis is one of the most globally widespread zoonosis caused by pathogenic spirochetes from genus Leptospira spp. Icteric leptospirosis is a severe form of the disease which affects 5-15% of patients with leptospirosis, is often rapidly progressive and has a high mortality rate. Early diagnosis of leptospirosis is crucial for initiation of adequate antimicrobial therapy in order to prevent the advent of complications and reduce mortality. Literature offers an increasing amount of evidence that early application of corticosteroids affects the course of the disease, prevents the onset of multiorgan failure, reduces mortality and reduces the duration of hospitalization. This paper is a case report of a patient with severe icteric leptospirosis who was treated with antimicrobial and corticosteroid therapy. The patient recovered fully, with no remaining morbidity after the severe disease.
Databáze: OpenAIRE
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