Successful Treatment of Brain Ischemia with Supplementation Therapy in a Patient with Hyperhomocysteinemia

Autor:	Marjan Zaletel, Aleš Ambrožič, Nataša Gašperšič, Matija Zupan, Bojana Žvan
Jazyk:	angličtina
Rok vydání:	2011
Předmět:	Hiperhomocisteinemija Ishemijski napadaj prolazni Metilen-tetrahidrofolat reduktaza Vitamini Dodaci hrani Hyperhomocysteinemia Ischemic attacks transient Methylenetetrahydrofolate reductase Vitamins Dietary supplement
Zdroj:	Acta clinica Croatica Volume 50 Issue 4
ISSN:	1333-9451 0353-9466
Popis:	The effectiveness of homocysteine-lowering therapy on stroke prevention is still unclear. Although randomized controlled epidemiological trials have yielded mixed findings, a multicenter trial did not show any beneficial effect. Genetic studies are still lacking. Therefore, we report on a female patient with transient ischemic attacks and the thermolabile variant of methylenetetrahydrofolate reductase (TT genotype), who benefited from supplemental therapy for homocysteine lowering. Učinkovitost terapije snižavanja homocisteina u prevenciji moždanog udara ostaje nejasnom. Iako su randomizirana kontrolirana epidemiološka ispitivanja polučila mješovite nalaze, jedna multicentrična studija nije pokazala nikakav koristan učinak, dok genetičke studije još uvijek nedostaju. Prikazuje se slučaj bolesnice s prolaznim ishemijskim napadajima i termolabilnom varijantom metilen-tetrahidrofolat reduktaze (TT genotip) u koje se terapija dodacima hrani radi snižavanja homocisteina pokazala korisnom.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od_______951::2424490c0c40898213eb99fb5666b08c https://hrcak.srce.hr/84587 Zobrazit plný text záznamu