Amino acid derivarives Part 1. Synthesis, antiviral and antitumor evaluation of new alpha-amino acid esters bearing coumarin side chain

Autor:	NAJIM A. AL-MASOUDI, IMAN A. AL-MASOUDI, IBRAHIM A. I. ALI, YASEEN A: AL-SOUD, BAHJAT SAEED, PAOLO LA COLLA
Jazyk:	angličtina
Rok vydání:	2006
Předmět:	aminokiseline antitumorsko djelovanje antivirusno djelovanje kumarin amino acids antitumor activity antiviral activity coumarin coupling reaction
Zdroj:	Acta Pharmaceutica Volume 56 Issue 2
ISSN:	1846-9558 1330-0075
Popis:	A series of amino acid esters bearing coumarin (3-15) were synthesized and evaluated, in vitro, against HIV-1, and bovine viral diarrhea virus (BVDV). The in vitro cytotoxicity of 3-10 and 12 were assyed against a panel of tumor cell lines consisting of CD4 human T-cells. Compound 14 showed inhibition of HIV-1 with EC50 > 1.6 microg mL-1, meanewhile compound 9 exhibited activity against leukaemia (MT4) with CC50 = 24 micromol L-1). U radu je opisana sinteza estera aminokiselina s kumarinskim ostatkom 3-15. Ispitano je antivirusno djelovanje sintetiziranih spojeva na HIV-1 i goveđi virus diareje (BVDV) te in vitro citotoksičnost spojeva 3-10 i 12 na tumorskim linijama CD4 humanih T-stanica. Spoj 14 pokazao je inhibiciju HIV-1 s EC50 > 1.6 microg mL-1, dok je spoj 9 djelotvoran na leukemiju (MT4) s CC50 = 24 micromol L-1.
Databáze:	OpenAIRE
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