| Autor: |
Ananworanich, J., Apornpong, T., Kosalaraksa, P., Jaimulwong, T., Hansudewechakul, R., Pancharoen, C., Bunupuradah, T., Chandara, M., Puthanakit, T., Ngampiyasakul, C., Wongsawat, J., Kanjanavanit, S., Luesomboon, W., Klangsinsirikul, P., Ngo-Giang-Huong, Nicole, Kerr, S. J., Ubolyam, S., Mengthaisong, T., Gelman, R. S., Pattanapanyasat, K., Saphonn, V., Ruxrungtham, K., Shearer, W. T. |
| Rok vydání: |
2010 |
| Předmět: |
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| Popis: |
Background: There are limited data on the immune profiles of HIV-positive children compared with healthy controls, and no such data for Asian children. Objectives: To immunophenotype HIV-positive Asian children, including long-term nonprogressors (LTNPs), compared with age-matched healthy controls. Methods: We used flow cytometry to analyze 13 lymphocyte and monocyte subsets from 222 untreated, HIV-positive children with 15% to 24% CD4(+) T cells and no AIDS-related illnesses and 142 healthy children (controls). Data were compared among age categories. Profiles from LTNPs (n = 50), defined as children >= 8 years old with CD4(+) T-cell counts >= 350 cells/mm(3), were compared with data from age-matched non-LTNPs (n = 17) and controls (n = 53). Results: Compared with controls, HIV-positive children had lower values (cell count per mm(3) and percent distribution) for T-H cells and higher values for cytotoxic T cells, with reductions in populations of naive T-H and cytotoxic T cells, B cells, and natural killer (NK) cells. HIV-positive children had high values for activated T-H and cytotoxic T cells. Compared with non-LTNPs, LTNPs had higher values of T-H and cytotoxic T cells, naive and memory T-cell subsets, and B and NK cells. Surprisingly, counts of activated T-H and cytotoxic T cells were also higher among LTNPs. LNTPs were more frequently male. Conclusion: Untreated, HIV-infected Asian children have immune profiles that differ from those of controls, characterized by low values for T-H cells, naive T cells, B cells, and NK cells but high values for cytotoxic, activated T-H, and cytotoxic T cells. The higher values for activated T cells observed in LTNPs require confirmation in longitudinal studies. (J Allergy Clin Immunol 2010;126:1294-301.) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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