| Autor: |
Mani, L., Jullian, Valérie, Mourkazel, B., Valentin, A., Dubois, J., Cresteil, T., Folcher, Eric, Hooper, J. N. A., Erpenbeck, D., Aalbersberg, W., Debitus, Cécile |
| Rok vydání: |
2012 |
| Předmět: |
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| Popis: |
Four samples of Suberea ianthelliformis were investigated and furnished five new and 13 known brominated tyrosine-derived compounds. Two of the new compounds were identified as araplysillin N20-formamide and its N-oxide derivative. Three other new compounds, araplysillins IV, V, and VI, were isolated and identified as analogs of araplysillin II. Most of these compounds exhibit moderate inhibitory activities against chloroquine-resistant and -sensitive strains of Plasmodium falciparum, and were investigated for their PFTase inhibitory properties. The chemical content of the investigated sponges is correlated with their molecular phylogeny. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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