Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models
| Autor: | Homberg, J. R., Kyzar, E. J., Nguyen, M., Norton, W. H., Pittman, J., Poudel, M. K., Gaikwad, S., Nakamura, S., Koshiba, M., Yamanouchi, H., Scattoni, M. L., Ullman, J. F. P., Diamond, D. M., Kaluyeva, A. A., Parker, M. O., Klimenko, V. M., Apryatin, S. A., Brown, R. E., Song, C., Gainetdinov, R. R., Gottesman, I. I., Kalueff, A. V. |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
EXPERIMENTAL ANIMAL
GENETIC SUSCEPTIBILITY OXIDOPAMINE COMPULSION PSYCHOLOGICAL MODEL MENTAL DISEASE GILLES DE LA TOURETTE SYNDROME GENOTYPE ENVIRONMENT INTERACTION AUTISTIC DISORDER PHENOTYPE MODEL ORGANISM EXPERIMENTAL BEHAVIORAL TEST NEUROGENESIS ANXIETY DISORDER BEHAVIORAL RESEARCH DAT GENE MOTOR DYSFUNCTION EMOTION LEARNING AND MEMORY TEST BEHAVIOR DISORDER NONHUMAN REVIEW SEIZURE SNAP25 GENE AUTISM BRAIN PRIORITY JOURNAL NEURODEVELOPMENTAL DISORDERS ENVIRONMENTAL ENRICHMENT MONOAMINE DERIVATIVE SOCIAL BEHAVIOR AUTISM SPECTRUM DISORDER EXPERIMENTAL MODEL TRANSLATIONAL RESEARCH ANIMALS PRECLINICAL STUDY HUMAN COGNITIVE DEVELOPMENT ANIMAL EXPERIMENTAL TRANSLATIONAL NEUROBEHAVIORAL MODEL GENE INTEREST RESTRICTION NERVOUS SYSTEM DEVELOPMENT NEUROTOXICITY NEURODEVELOPMENTAL DISORDER BEHAVIORAL INFLEXIBILITY GENETIC POLYMORPHISM ATTENTION DEFICIT DISORDER COMORBIDITY |
| Zdroj: | Neurosci. Biobehav. Rev. Neuroscience and Biobehavioral Reviews |
| Popis: | Neurodevelopmental disorders (NDDs) are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development. Resulting in cognitive, social, motor, language and affective disabilities, common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Affecting neurogenesis, glia/neuronal proliferation and migration, synapse formation and myelination, aberrant neural development occurs over a substantial period of time. Genetic, epigenetic, and environmental factors play a key role in NDD pathogenesis. Animal models are an indispensable tool to study NDDs. Paralleling clinical findings, we comprehensively evaluate various preclinical tests and models which target key (social, cognitive, motor) neurobehavioral domains of ASD and other common NDDs. Covering both traditional (rodent) and alternative NDD models, we outline the emerging areas of research and emphasize how preclinical models play a key role in gaining translational and mechanistic insights into NDDs and their therapy. © 2016 Elsevier Ltd. |
| Databáze: | OpenAIRE |
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