Synthesis and Characterization of a Novel Biocompatible Alloy, ti-nb-zr-ta-sn

Autor: Khrunyk, Y. Y., Ehnert, S., Grib, S. V., Illarionov, A. G., Stepanov, S. I., Popov, A. A., Ryzhkov, M. A., Belikov, S. V., Xu, Z., Rupp, F., Nüssler, A. K.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
LIMIT OF QUANTITATION
SCANNING ELECTRON MICROSCOPY
ALLOYS
CHEMICAL PHENOMENA
CHEMICAL COMPOSITION
SURFACE PROPERTY
BIOCOMPATIBILITY
COMPARATIVE STUDY
SAOS-2 CELL LINE
THP-1 CELL LINE
CHEMISTRY
HYDROPHOBIC AND HYDROPHILIC INTERACTIONS
HUMAN CELL
EXTRACELLULAR TRAP
CELL ADHESION
ELECTRON DIFFRACTION
NIOBIUM
HUMAN
HUMANS
TRANSMISSION ELECTRON MICROSCOPY
LOW-MODULUS TI ALLOYS
TITANIUM ALLOY (TIAL6V4)
ENZYME LINKED IMMUNOSORBENT ASSAY
X RAY DIFFRACTION
CONTACT ANGLE
IN VITRO STUDY
NEUTROPHIL
DRUG EFFECT
CELL DENSITY
YOUNG MODULUS
BIOCOMPATIBLE MATERIALS
SYNTHESIS
ELASTIC MODULUS
ZIRCONIUM
IOMATERIAL
OSTEOBLASTS
BIOMEDICAL IMPLANTS
QUANTITATIVE ANALYSIS
TENSILE PROPERTIES
ARTICLE
OSTEOBLAST
MATERIALS TESTING
TANTALUM
PROSTHESES AND IMPLANTS
CHEMICAL STRUCTURE
technology
industry
and agriculture
ALLOY
TENSILE STRENGTH
CELL STRUCTURE
equipment and supplies
PROSTHESES AND ORTHOSES
CELL VIABILITY
CONTROLLED STUDY
TIN
TITANIUM
PROCEDURES
CELL PROLIFERATION
PERIPHERAL BLOOD MONONUCLEAR CELL
THP-1 CELLS
RESAZURIN ASSAY
CELL ACTIVITY
MACROPHAGE
NORMAL HUMAN
O2 PLASMA TREATMENT
HYDROPHILICITY
Zdroj: Int. J. Mol. Sci.
International Journal of Molecular Sciences
Popis: Many current-generation biomedical implants are fabricated from the Ti-6Al-4V alloy because it has many attractive properties, such as low density and biocompatibility. However, the elastic modulus of this alloy is much larger than that of the surrounding bone, leading to bone resorption and, eventually, implant failure. In the present study, we synthesized and performed a detailed analysis of a novel low elastic modulus Ti-based alloy (Ti-28Nb-5Zr-2Ta-2Sn (TNZTS alloy)) using a variety of methods, including scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and tensile test. Additionally, the in vitro biocompatibility of the TNZTS alloy was evaluated using SCP-1, SaOs-2, and THP-1 cell lines and primary human osteoblasts. Compared to Ti-6Al-4V, the elastic modulus of TNZTS alloy was significantly lower, while measures of its in vitro biocompatibility are comparable. O2 plasma treatment of the surface of the alloy significantly increased its hydrophilicity and, hence, its in vitro biocompatibility. TNZTS alloy specimens did not induce the release of cytokines by macrophages, indicating that such scaffolds would not trigger inflammatory responses. The present results suggest that the TNZTS alloy may have potential as an alternative to Ti-6Al-4V. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Funding: The experimental work was funded by the State Assignment (Russian Federation, Grant No. 0836-2020-0020) and DAAD together with the Ministry of Education and Science of the Russian Federation within the Michael Lomonosov Program (project No. 57447934).
Databáze: OpenAIRE
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