Synthesis and Characterization of a Novel Biocompatible Alloy, ti-nb-zr-ta-sn
Autor: | Khrunyk, Y. Y., Ehnert, S., Grib, S. V., Illarionov, A. G., Stepanov, S. I., Popov, A. A., Ryzhkov, M. A., Belikov, S. V., Xu, Z., Rupp, F., Nüssler, A. K. |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
LIMIT OF QUANTITATION
SCANNING ELECTRON MICROSCOPY ALLOYS CHEMICAL PHENOMENA CHEMICAL COMPOSITION SURFACE PROPERTY BIOCOMPATIBILITY COMPARATIVE STUDY SAOS-2 CELL LINE THP-1 CELL LINE CHEMISTRY HYDROPHOBIC AND HYDROPHILIC INTERACTIONS HUMAN CELL EXTRACELLULAR TRAP CELL ADHESION ELECTRON DIFFRACTION NIOBIUM HUMAN HUMANS TRANSMISSION ELECTRON MICROSCOPY LOW-MODULUS TI ALLOYS TITANIUM ALLOY (TIAL6V4) ENZYME LINKED IMMUNOSORBENT ASSAY X RAY DIFFRACTION CONTACT ANGLE IN VITRO STUDY NEUTROPHIL DRUG EFFECT CELL DENSITY YOUNG MODULUS BIOCOMPATIBLE MATERIALS SYNTHESIS ELASTIC MODULUS ZIRCONIUM IOMATERIAL OSTEOBLASTS BIOMEDICAL IMPLANTS QUANTITATIVE ANALYSIS TENSILE PROPERTIES ARTICLE OSTEOBLAST MATERIALS TESTING TANTALUM PROSTHESES AND IMPLANTS CHEMICAL STRUCTURE technology industry and agriculture ALLOY TENSILE STRENGTH CELL STRUCTURE equipment and supplies PROSTHESES AND ORTHOSES CELL VIABILITY CONTROLLED STUDY TIN TITANIUM PROCEDURES CELL PROLIFERATION PERIPHERAL BLOOD MONONUCLEAR CELL THP-1 CELLS RESAZURIN ASSAY CELL ACTIVITY MACROPHAGE NORMAL HUMAN O2 PLASMA TREATMENT HYDROPHILICITY |
Zdroj: | Int. J. Mol. Sci. International Journal of Molecular Sciences |
Popis: | Many current-generation biomedical implants are fabricated from the Ti-6Al-4V alloy because it has many attractive properties, such as low density and biocompatibility. However, the elastic modulus of this alloy is much larger than that of the surrounding bone, leading to bone resorption and, eventually, implant failure. In the present study, we synthesized and performed a detailed analysis of a novel low elastic modulus Ti-based alloy (Ti-28Nb-5Zr-2Ta-2Sn (TNZTS alloy)) using a variety of methods, including scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and tensile test. Additionally, the in vitro biocompatibility of the TNZTS alloy was evaluated using SCP-1, SaOs-2, and THP-1 cell lines and primary human osteoblasts. Compared to Ti-6Al-4V, the elastic modulus of TNZTS alloy was significantly lower, while measures of its in vitro biocompatibility are comparable. O2 plasma treatment of the surface of the alloy significantly increased its hydrophilicity and, hence, its in vitro biocompatibility. TNZTS alloy specimens did not induce the release of cytokines by macrophages, indicating that such scaffolds would not trigger inflammatory responses. The present results suggest that the TNZTS alloy may have potential as an alternative to Ti-6Al-4V. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Funding: The experimental work was funded by the State Assignment (Russian Federation, Grant No. 0836-2020-0020) and DAAD together with the Ministry of Education and Science of the Russian Federation within the Michael Lomonosov Program (project No. 57447934). |
Databáze: | OpenAIRE |
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