Zebrafish models in neuropsychopharmacology and CNS drug discovery
| Autor: | Khan, K. M., Collier, A. D., Meshalkina, D. A., Kysil, E. V., Khatsko, S. L., Kolesnikova, T., Morzherin, Y. Y., Warnick, J. E., Kalueff, A. V., Echevarria, D. J. |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
ZEBRA FISH
animal structures CENTRAL NERVOUS SYSTEM AGENTS PSYCHOPHARMACOLOGY DRUG SCREENING CENTRAL NERVOUS SYSTEM DISEASE NEUROLEPTIC AGENT SMALL MOLECULE LIBRARIES ALCOHOL AUTOMATION ANIMAL MODEL SYNTHESIS DRUG SENSITIVITY DISEASE MODEL ANXIETY DISORDER PSYCHOSIS THERAPEUTIC USE AMPHETAMINE DERIVATIVE NICOTINE CHEMISTRY PSYCHEDELIC AGENT NONHUMAN REVIEW DRUG TARGETING NERVE DEGENERATION PRIORITY JOURNAL ANTICONVULSIVE AGENT ALZHEIMER DISEASE DRUG DEVELOPMENT EPILEPSY GENETIC MODEL DISEASE MODELS ANIMAL ZEBRAFISH fungi ANIMALS PRECLINICAL STUDY CENTRAL NERVOUS SYSTEM MOLECULAR LIBRARY ANIMAL DRUG EVALUATION PRECLINICAL CENTRAL NERVOUS SYSTEM DISEASES DEPRESSION SEDATIVE AGENT DRUG DISCOVERY AMYOTROPHIC LATERAL SCLEROSIS DRUG ABUSE HIGH THROUGHPUT SCREENING COCAINE GENETIC SCREENING |
| Zdroj: | British Journal of Pharmacology |
| Popis: | Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. As well as covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and the discovery of novel drug targets. © 2017 The British Pharmacological Society The study was coordinated through the International Zebrafish Neuroscience Research Consortium (ZNRC), and this collaboration was funded by St. Petersburg State University, Ural Federal University and Guangdong Ocean University. A.V.K. is the Chair of ZNRC, and his research is supported by the Russian Foundation for Basic Research (RFBR) grant 16-04-00851. |
| Databáze: | OpenAIRE |
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