Zebrafish models for attention deficit hyperactivity disorder (ADHD)
| Autor: | Fontana, B. D., Franscescon, F., Rosemberg, D. B., Norton, W. H. J., Kalueff, A. V., Parker, M. O. |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
ZEBRA FISH
animal structures GENETICS VIRUS VECTOR PATHOPHYSIOLOGY CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT TARGETING INDUCED LOCAL LESIONS IN GENOMES METHOD VIRAL VECTOR MEDIATED INSERTIONAL MUTAGENESIS ANIMAL MODEL PHENOTYPE BEHAVIOR ANIMAL behavioral disciplines and activities ANIMAL EXPERIMENT DISEASE MODEL EXPERIMENTAL BEHAVIORAL TEST DOPAMINE TRANSLATIONAL MEDICAL RESEARCH NORADRENALINE mental disorders ADHD GENETIC PROCEDURES NONHUMAN REVIEW BRAIN ANTISENSE OLIGONUCLEOTIDE PRIORITY JOURNAL DRUG DEVELOPMENT MONOAMINERGIC SYSTEM MUTAGENESIS MALE ZEBRAFISH DISEASE MODELS ANIMAL SEROTONIN TRANSLATIONAL RESEARCH ANIMALS TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE ANIMAL ANIMAL BEHAVIOR FEMALE NEUROSCIENCE ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY SPECIES COMPARISON ATTENTION DEFICIT DISORDER OPTOGENETICS BEHAVIOR |
| Zdroj: | Neurosci. Biobehav. Rev. Neuroscience and Biobehavioral Reviews |
| Popis: | Attention deficit hyperactivity disorder (ADHD) is a common, debilitating neurodevelopmental disorder associated with inattentiveness, pathological hyperactivity and impulsivity. Despite the mounting human and animal evidence, the neurological pathways underlying ADHD remain poorly understood. Novel translational model organisms, such as the zebrafish (Danio rerio), are becoming important tools to investigate genetic and pathophysiological mechanisms of various neuropsychiatric disorders. Here, we discuss ADHD etiology, existing animal models and their limitations, and emphasize the advantages of using zebrafish to model ADHD. Overall, the growing utility of zebrafish models may improve our understanding of ADHD and facilitate drug discovery to prevent or treat this disorder. © 2019 Elsevier Ltd |
| Databáze: | OpenAIRE |
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