| Autor: |
Almendáriz-Palacios, C, Gillespie, ZE, Janzen, M, Martinez, V, Bridger, JM, Harkness, TAA, Mousseau , DD, Eskiw, CH |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
This article belongs to the Special Issue Protein Structure, Function and Dynamics in Diseases and Therapeutics © 2020 by the authors. Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging. One proteinaceous structure underlying the nuclear envelope—the nuclear lamina—coordinates essential processes including DNA repair, genome organization and epigenetic and transcriptional regulation. Loss of proteostasis within the nuclear lamina results in accumulation of proteins, disrupting these essential functions, either via direct interactions of protein aggregates with the lamina or by altering systems that maintain lamina structure. Here we discuss the links between proteostasis and disease of the nuclear lamina, as well as how manipulating specific proteostatic pathways involved in protein clearance could improve cellular health and prevent/reverse disease. College of Graduate Studies and Postdoctoral Studies (U of S); Vanier Canada Scholarship; University of Saskatchewan Devolved Scholarship program; Alzheimer Society of Saskatchewan; the Saskatchewan Health Research Foundation; Natural Sciences and Engineering Council of Canada (NSERC); Canadian Institutes of Health Research (CIHR) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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