| Autor: |
Ling, Frederike, Hoelscher, Arnulf, Vallböhmer, Daniel, Schmidt, Daniel, Picker, Susanne, Gathof, Birgit, Bollschweiler, Elfriede, Schneider, Paul |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Popis: |
Background: Perioperative transfusion of allogeneic blood has been hypothesized to have an immunomodulatory effect and influence survival in several cancer types. This study evaluates the association between receipt of leucocyte-depleted and non-depleted allogeneic blood and survival following esophagectomy for cancer. Methods: A retrospective analysis was performed including 291 patients with esophageal cancers who underwent transthoracic en bloc esophagectomy and extended mediastinal lymphadenectomy. Neoadjuvant chemoradiation was administered in 152 (52.2%) patients. Perioperative blood transfusions were quantified and the potential prognostic cutoff for transfused units was calculated according to LeBlanc. Results: The median number of perioperative blood transfusions was 2 (0-24), and 106 patients (36.4%) received no transfusions. Patients with one or less blood transfusion showed a significantly improved survival compared to patients receiving more than one unit (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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