A Novel Synthesis of rac-5-(Hydroxymethyl)-l-Tetrahydro-21-oxofur-31-yl)-1H-pyrrole-2-carboxaldehyde
| Autor: | Hayoz, Pascal, Aeby, Anton, Neier, Reinhard |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Popis: | A novel six-step synthesis of rac-5-(hydroxymethyl)-l-(tetrahydro-2'-oxo-fur-3'-yl)-lH-pyrrole-2-carboxaldehyde (rac-1) starting from 2-methylfuran has been developed. The key step is the formation of rac-2-methyl-l-(tetrahydro-2'-oxofur-3'-yl)- lH-pyrrole (rac-7) according to the Clauson-Kaas procedure. Subsequent Vilsmeier formylation, oxidation with lead tetraacetate, and enzymatic hydrolysis led to rac-1. |
| Databáze: | OpenAIRE |
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