| Autor: |
Lirk, P., Verhamme, C., Boeckh, R., Stevens, M. F., ten Hoope, W., Gerner, P., Blumenthal, S., de Girolami, U., van Schaik, I. N., Hollmann, M. W., Picardi, S., Galley, H. F. |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Popis: |
Background The neuropathy of type II diabetes mellitus (DM) is increasing in prevalence worldwide. We aimed to test the hypothesis that in a rodent model of type II DM, neuropathy would lead to increased neurotoxicity and block duration after lidocaine-induced sciatic nerve block when compared with control animals. Methods Experiments were carried out in Zucker diabetic fatty rats aged 10 weeks (early diabetic) or 18 weeks (late diabetic, with or without insulin 3 units per day), and age-matched healthy controls. Left sciatic nerve block was performed using 0.2 ml lidocaine 2%. Nerve conduction velocity (NCV) and F-wave latency were used to quantify nerve function before, and 1 week after nerve block, after which sciatic nerves were used for neurohistopathology. Results Early diabetic animals did not show increased signs of nerve dysfunction after nerve block. In late diabetic animals without insulin vs control animals, NCV was 34.8 (5.0) vs 41.1 (4.1) ms s−1 (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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