Silizium-Nanoribbon-Feld-Effekt-Transistoren zur Kopplung an elektroaktive Zellen
| Autor: | Jansen, Michael |
|---|---|
| Přispěvatelé: | Offenhäusser, Andreas |
| Jazyk: | němčina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Jülich : Forschungszentrum Jülich, Zentralbibliothek, Schriften des Forschungszentrums Jülich : Reihe Schlüsseltechnologien 82, XVI, 181 S. : Ill., graph. Darst. (2014). = Zugl.: Aachen, Techn. Hochsch., Diss., 2013 |
| Popis: | During the past decades micro- and nanostructured devices for coupling to electro active cells were develpoed. This devices can lead to a variety of new possibilties to investigate signal transduction in cell networks as well as new mediacl applications, e.g. neuroprotetics. In this work a biosensor chip consisting of 30 silicon nanoribbon fied-effect transistors (NRFETs) arranged in an array was developed. The biosensores were successfully fabricated and used for signal detection from electro active cells. The fabrication process was developed and optimized for the use as biosensors. Electrical characterization showed typical transistor behaviour with very low hyteresis effect enabling the NRFETs to be used as biosensors. Additionally, the noise of the NRFETs itself and the amplifier system was characterized. The bisensores were then used for pH detection exhibiting a sensitivity of 42 mV/dec. Secondly, the NRFETs were used to detect action potentials from electro active cells. The detection of the action potentials from cardiac cells with a signal-to-noise ratio of 23 was successfully demonstrated. For detecting action potentials from neurons further improvements were proposed. |
| Databáze: | OpenAIRE |
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