| Autor: |
Doron, D. A., McCarron, D. M., Heldman, E., Sirén, Anna-Leena, Spatz, M., Feuerstein, G., Pollard, H. B., Hallenbeck, J. M. |
| Jazyk: |
angličtina |
| Rok vydání: |
1992 |
| Předmět: |
|
| Popis: |
The amounts of tissue factor (TF) expressed by brain microvascular endothelial cells (BMECs) from normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were compared after stimulating the cells with different doses of lipopolysaccharide (LPS), thrombin, phorbol myristic acid (PMA), Ca\(^{2+}\)·ionophore (A23187), or tumor necrosis factor (TNF) and interleukin·l (IL.l). Treatment ofcultured BMECs fron. WKY and SHR with all of these factors dose·dependently increased their total amount of TF; no substantive differences in the Ieveis of enhanced TF expression were observed between WKY and SHR BMECs. We conclude that stimulated endothelium from rats with hypertension, a major stroke risk factor, is not hyperresponsive with respect to TF expression when compared to normotensive controls. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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