| Autor: |
Moll, Heidrun, Müller, Christoph, Gillitzer, Reinhard, Fuchs, Harald, Röllinghoff, Martin, Simon, Markus M., Kramer, Michael D. |
| Jazyk: |
angličtina |
| Rok vydání: |
1991 |
| Předmět: |
|
| Popis: |
The expression of T-cell-associated serine proteinase 1 (MTSP-1) in vivo during Leishmania major infection was analyzed in genetically resistant C57BL/6 mice and in genetically susceptible BALB/c mice. Using a monoclonal antibody as well as an RNA probe specific for MTSP-1 to stain tissue sections, we found T cells expressing MTSP-1 in skin lesions and spleens of mice of both strains. In skin lesions, MTSP-1-positive T cells could be detected as early as 3 days after infection. Most importantly, the frequency of T cells expressing MTSP-1 was significantly higher in susceptible BALB/c mice than in resistant C57BL/6 mice. These findings suggest that MTSP-1 is associated with disease-promoting T cells and that it may be an effector molecule involved in the pathogenesis of cutaneous leishmaniasis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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