| Autor: |
Tacke, Reinhold, Wagner, S. A., Brakmann, S., Wuttke, F., Eilert, U., Fischer, L., Syldatk, C. |
| Jazyk: |
angličtina |
| Rok vydání: |
1993 |
| Předmět: |
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| Popis: |
Starting from chlorodimethyl(phenyl)silane (3), acetyldimethyl(phenyl)silane (l) was prepared by a two-step synthesis in a total yield of 90% [PhMe\(_2\)SiCl (3)-> PhMe\(_2\)SiCCOMe)=CH\(_2\) (4)-> PhMe\(_2\)SiC(O)Me (1)]. The prochiral acetylsilane 1 was transfonned enantioselectively into (R)-(1-hydroxyethyl)dimethyl(phenyl)silane [(R)-2] using plant cell Suspension cultures of Symphytum officinale L. or Ruta graveolens L. Under preparative conditions (300-mg scale, not optimized), (R)-2 was isolated in 15% (Symphytum) and 9% yield (Ruta), respectively. The enantiomeric purities of the products were 81% ee (Syrnphytum) and 60% ee (Ruta), respectively. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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