Relationship between gastroesophageal reflux symptoms and 24 h esophageal pH measurement in patients with normal or minimally abnormal upper endoscopies

Autor: Csendes J, Attila, Rencoret P, Guillermo, Beltrán S, Marcelo, Smok S, Gladys, Henríquez D, Ana
Jazyk: Spanish; Castilian
Rok vydání: 2004
Předmět:
Zdroj: Revista médica de Chile, Volume: 132, Issue: 1, Pages: 19-25, Published: JAN 2004
Popis: Heartburn and regurgitation are considered highly specific symptoms of gastroesophageal reflux. A considerable number of patients with these symptoms do not have endoscopic signs of esophagitis. Aim: To study the relationship between gastroesophageal reflux symptoms and 24 h esophageal pH mesurement in patients with normal or near normal endoscopic findings. Patients and methods: One hundred eighty six patients with persistent reflux symptoms and absence of severe endoscopic esophagitis were studied. Pathological studies of esophageal biopsies, manometry and 24 h esophageal pH measurements were performed in all. Results: Abnormal acid reflux was found in 131 patients (70%). No differences in the frequency of symptoms, gender or pathologic findings were observed between patients with or without abnormal acid reflux. However, a higher frequency of esophageal erosions and a lower resting pressure of the inferior sphincter of the esophagus was observed in patients with abnormal acid reflux. Conclusions: Thirty percent of patients with heartburn and regurgitation did not have abnormal acid reflux. Therefore, these symptoms are not specific for gastroesophageal reflux (Rev Méd Chile 2004; 132: 19-25).
Databáze: OpenAIRE