| Autor: |
Tapia P, Cecilia, González A, Patricia, Pereira A, Angélica, Pérez G, Jorge, Noriega R, Luis M, Palavecino R, Elizabeth |
| Jazyk: |
Spanish; Castilian |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Revista médica de Chile, Volume: 131, Issue: 5, Pages: 515-519, Published: MAY 2003 |
| Popis: |
Background: Oropharyngeal candidiasis (OPC) and esophageal candidiasis (EPC) are frequent complications in AIDS patients. The use of Fluconazole, an effective and a low toxicity drug, has been associated to the emergency of secondary resistant strains. For this reason, in vitro antifungal susceptibility tests are necessary to predict a therapeutic failure. Etest® is an easy to perform alternative test, that has showed a good agreement with the broth microdilution reference method (NCCLS, document M27-A). Aim: To measure the susceptibility of C. albicans isolates from AIDS patients complicated with OPC and EPC to Amphotericin B (AmB) and Fluconazole (Flu) using Etest®. Material and methods: Twenty strains from 20 AIDS patients were studied. AmB was tested in RPMI 1640 agar and Flu in Casitone agar. Results: All studied strains showed minimal inhibitory concentrations (MICs) 256 mg/mL) was isolated from a patient previously treated with Flu. Conclusions: In AIDS patients with OPC and EPC, the susceptibility to Flu of the isolates should be screened, to detect resistant strains. Etest®; is a reliable alternative in these cases, for laboratories that cannot use the reference method (Rev Méd Chile 2003; 131: 515-19). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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