Osteoporosis associated to indinavir in an HIV infected patient: Case report and review

Autor: BASSO B., MARTÍN, GONZÁLEZ V., GILBERTO, PÉREZ G., JORGE, NORIEGA R., LUIS M, MALEBRAN R., ANDREA
Jazyk: Spanish; Castilian
Rok vydání: 2003
Předmět:
Zdroj: Revista chilena de infectología, Volume: 20, Issue: 4, Pages: 253-256, Published: 2003
Popis: Se presenta el caso de un paciente de 45 años portador de VIH que desarrolló osteoporosis secundaria a 33 meses de exposición a sulfato de indinavir como parte de su terapia antiretroviral (TAR). Su manejo consistió en alendronato, calcio y vitamina D junto con modificación de su TAR: suspensión de indinavir e inicio de efavirenz. Luego de 16 meses de tratamiento se verificó un incremento en la densidad mineral ósea de 11% en promedio. No ocurrieron fracturas ni se constató efectos adversos o interacciones medicamentosas. Se revisa la literatura The case of a 45 year-old HIV patient that developed secondary osteoporosis to 33 months of intake indinavir sulfate as part of its high activity antiretroviral therapy (HAART) is presented. His management consisted on alendronate, calcium and vitamin D together with modification of his antiretroviral therapy: indinavir moved to efavirenz. After 16 months of treatment an increment on the average in the bone mineral density of 11% was verified. During this time there were neither fractures, nor adverse effects or medication interactions. The literature is reviewed.
Databáze: OpenAIRE