| Autor: |
Hurtado, Claudia, Encina, Gonzalo, Wielandt, Ana María, Zárate, Alejandro José, Castro, Magdalena, Carrillo, Katya, Kronberg, Udo, López-Köstner, Francisco |
| Jazyk: |
Spanish; Castilian |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Revista médica de Chile, Volume: 142, Issue: 11, Pages: 1407-1414, Published: NOV 2014 |
| Popis: |
Background: The molecular testing of KRAS mutation status in metastatic colorectal cancer patients is mandatory to identify patients eligible for anti-epidermal growth factor receptor monoclonal antibody therapy. Aim: To report the frequency of KRAS gene mutations in Chilean patients with colorectal cancer (CRC). Material and Methods: A cohort of 262 Chilean patients with CRC aged 26 to 90 years (53% males), was studied. KRAS mutation status was analyzed by real-time polymerase chain reaction and correlated with clinicopathological data. Results: Ninety-eight patients (37%) were positive for KRAS mutations. G12D was the most common mutation with a frequency of 36.7%, followed by G12V (25.5%), G13D (17.3%), G12A (7.1%), G12C (6.1%), G12S (5.1%) and G12R (2%). The frequency of the mutation in left, right colon and rectal tumors was 37.8, 32.6 and 44.9%, respectively. Among tumors with mutations, 86.7% were well or moderately differentiated tumors and the rest were poorly differentiated. No significant associations between KRAS gene mutations and other clinicopathological features of the tumor were observed. Conclusions: The frequencies of KRAS mutations reported in this study are similar to frequencies reported for European and North-American populations, lower than in a Spanish study and higher than in a Peruvian study. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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