| Autor: |
Freitas, Luana Cristina de, Sousa, Luiz Gustavo de, Leite, Guilherme Luciano, Scalize, Priscilla Hakime, Pitol, Dimitrius Leonardo, Righetti, Mariah Acioli, Ricardo, Vitória, Mello, Edneia Corrêa de, Bombonato-Prado, Karina Fittipaldi, Regalo, Simone Cecilio Hallak, Siessere, Selma |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
International Journal of Morphology, Volume: 37, Issue: 4, Pages: 1325-1330, Published: DEC 2019 |
| Popis: |
SUMMARY: Impairing osteoporosis progression is a challenge, and recently the role of antioxidants has been associated to bone metabolism. Green tea extract is rich in catechins, especially epigallocatechin gallate (EGCG), which may help control osteoporosis damage in bone tissue. This investigation evaluated the efficacy of green tea ingestion containing different concentrations of EGCG in calvaria bone repair of ovariectomized rats. Wistar rats (n=15) were ovariectomized and divided into 3 groups: ovariectomized (OVX), ovariectomized + GTE 15 % EGCG (OVX/GTE15), and ovariectomized + GTE 94 % EGCG (OVX/GTE94). Green tea extract was administered by gavage in the concentration of 50 mg/kg and sham group (n=5) received water. Bone defects were performed in the calvaria 60 days after ovariectomy followed by 4 weeks until euthanasia. Bone samples were collected to perform qualitative and quantitative histological analysis of bone formation. Data obtained were submitted to normality and ANOVA statistical test for p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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