Long term in vitro functional stability and recording longevity of fully integrated wireless neural interfaces based on the Utah Slant Electrode Array

Autor: Sharma, A., Rieth, L., Tathireddy, P., Harrison, R., Oppermann, H., Klein, M., Töpper, M., Jung, E., Normann, R., Clark, G., Solzbacher, F.
Přispěvatelé: Publica
Jazyk: angličtina
Rok vydání: 2011
Popis: We evaluate the encapsulation and packaging reliability of a fully integrated wireless neural interface based on a Utah Slant Electrode Array/integrated neural interface-recording version 5 (USEA/INI-R5) system by monitoring the long term in vitro functional stability and recording longevity. The INI encapsulated with 6 m Parylene-C was immersed in phosphate buffered saline (PBS) for a period of over 276 days (with the monitoring of the functional device still ongoing). The full functionality (wireless radio-frequency power, command and signal transmission) and the ability of the electrodes to record artificial neural signals even after 276 days of PBS soaking with little change (within 14%) in signal/noise amplitude constitute a major milestone in long term stability and allow us to study and evaluate the encapsulation reliability, functional stability and its potential usefulness for a wireless neural interface for future chronic implants.
Databáze: OpenAIRE