| Autor: |
Bauer, J., Kinast, S., Burger-Kentischer, A., Finkelmeier, D., Kleymann, G., Rayyan, W.A., Schröppel, K., Singh, A., Jung, G., Wiesmüller, K.-H., Rupp, S., Eickhoff, H. |
| Přispěvatelé: |
Publica |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Popis: |
Novel nontoxic (S)-2-aminoalkylbenzimidazole derivatives were found to be effective against Candida spp. at low micromolar concentrations using high-throughput screening with infected HeLa cells. A collection of analogues defined the chemical groups relevant for activity. The most active compound was characterized by transcriptional analysis of the response of C. albicans Sc5314. (S)-2-(1-Aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole had a strong impact on membrane biosynthesis. Testing different clinically relevant pathogenic fungi showed the selectivity of the antimycotic activity against Candida species. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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