LUNG AND LIVER CHANGES DUE TO THE INDUCTION OF CIRRHOSIS IN TWO EXPERIMENTAL MODELS
| Autor: | FERRARI, Renata Salatti, TIEPPO, Mauricio, ROSA, Darlan Pase da, FORGIARINI JR, Luiz Alberto, DIAS, Alexandre Simoes, MARRONI, Norma Possa |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Cirrose hepatica experimental
Pneumopatias Tetracloreto de Carbono uso diagnostico digestive system Liver cirrhosis experimental digestive system diseases Common bile duct physiopathology Ducto coledoco fisiopatologia Hepatopatias Carbon tetrachloride diagnostic use Modelos animais de doencas Diseases models animal Liver diseases Lung diseases |
| Zdroj: | Arquivos de Gastroenterologia, Volume: 50, Issue: 3, Pages: 208-213, Published: SEP 2013 |
| Popis: | Context To evaluate lung and liver changes in two experimental models using intraperitoneal carbon tetrachloride (CCl4) and bile duct ligation (BDL). Methods Twenty-four male Wistar rats were divided into a control group (CO) and an experimental group (EX). We evaluated the liver transaminases (AST, ALT, AP), arterial blood gases (PaO2, PCO2 and SpO2) and lipid peroxidation by TBARS (substances that react to thiobarbituric acid) and chemiluminescence. We also evaluated the antioxidant enzyme superoxide dismutase (SOD) and histology of lung tissue and liver. Results There were significant differences in AST, ALT, ALP and PaO2 between CO group and EX group (P |
| Databáze: | OpenAIRE |
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