| Autor: |
Bueno, Márcia Pereira, Gonçalves, Frances Lilian Lanhellas, Guadagnini, Dioze, Barini, Ricardo, Saad, Mario José Abdalla, Gallindo, Rodrigo Melo, Schmidt, Augusto Frederico, Sbragia, Lourenço |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Acta Cirurgica Brasileira, Volume: 28 Supplement 1, Pages: 03-07, Published: 2013 |
| Popis: |
PURPOSE: To evaluate the intrauterine growth restriction (IUGR) by the expression of IR-β, IRS-1, IRS-2, IGF-IRβ and Ikappaβ in experimental model of gastroschisis. METHODS: Pregnant rats at 18.5 days of gestation were submitted to surgery to create experimental fetal gastroschisis (term = 22 days) were divided in three groups: gastroschisis (G), control (C) and sham (S). Fetuses were evaluated for body weight (BW), intestinal (IW), liver (LW) and their relations IW/BW and LW/BW. IR-β and IGF-IRβ receptors, IRS-1 and IRS-2 substrates and Ikappaβ protein were analyzed by western blotting. RESULTS: BW was lower in G, the IW and IW / BW were greater than C and S (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
