| Autor: |
Baertschi, Steven, Dill, Allison, Sperry, David, Kramer, Timothy |
| Rok vydání: |
2014 |
| Zdroj: |
Society of Engineering Science 51st Annual Technical Meeting |
| Popis: |
A model for predicting the rate of degradation as a function of drug load was recently developed (J. Pharm. Sci., 101(11), 2012, 4170‑4177). In this case study, we explore both the mathematical model as well as the conceptual construct from which the model was developed. We applied the model to a formulated product of varying drug loads. Our results not only confirm the validity of the mathematical model, but also call into question the proposed conceptual construct. We will discuss the generality of the model and how the use of this model can speed development of lower dose drug formulations typically found in pediatric dosing regimens. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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