Source of angiopoietin-2 in the sera of women during pregnancy
| Autor: | Woolnough, C, Wang, Y, Kan, CY, Morris, JM, Tasevski, V, Ashton, AW |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Fetal Growth Retardation Placenta Keratin-7 Pregnancy Outcome Enzyme-Linked Immunosorbent Assay Antigens CD31 Trophoblasts Angiopoietin-2 Platelet Endothelial Cell Adhesion Molecule-1 Pregnancy Trimester First Cardiovascular System & Hematology Gene Expression Regulation Pregnancy Immunoglobulin G cardiovascular system Decidua Angiopoietin-1 Humans Female hormones hormone substitutes and hormone antagonists |
| Popis: | Placental development requires coordinated angiogenesis regulated by multiple factors including angiopoietins. Previously we demonstrated that the concentration of angiopoietin-2 (Ang-2) in the sera of women rises markedly in pregnancy in early gestation. This increase is reduced in pregnancies subsequently complicated by intrauterine growth restriction (IUGR). We now show that the concentration of Ang-2, but not Ang-1, in maternal serum is increased during normal pregnancy, peaking at the end of the first trimester. We also demonstrate that a key source of the elevated Ang-2 levels during pregnancy is decidual endothelial cells (DECs) but not cytotrophoblasts. Secretion of Ang-2 by DECs relies on the release from intracellular stores and the synthesis of new Ang-2 protein and is regulated by serum factors at a translational level. Further studies on the role of Ang-2 during pregnancy are warranted as well as the evaluation of Ang-2 as a marker to predict adverse pregnancy outcomes. © 2012. |
| Databáze: | OpenAIRE |
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