Peptide ligations accelerated by N-terminal aspartate and glutamate residues

Autor:	Thomas, GL, Hsieh, YSY, Chun, CKY, Cai, ZL, Reimers, JR, Payne, RJ
Rok vydání:	2011
Předmět:	Aspartic Acid Molecular Structure Venoms Organic Chemistry Glutamic Acid Hypoglycemic Agents Exenatide Esters Stereoisomerism Sulfhydryl Compounds Peptides Catalysis
Popis:	A novel application of intramolecular base catalysis confers enhanced reaction rates for aminolysis ligations between peptide thioesters and peptides bearing N-terminal aspartate or glutamate residues. The broad scope of this process and its application in the total synthesis of the diabetes drug exenatide is demonstrated. © 2011 American Chemical Society.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od_______363::57d4b46b9dac7f70fa841bc5ac51c2cf https://hdl.handle.net/10453/28184 Zobrazit plný text záznamu