| Autor: |
Bluher, A, Devan, WJ, Holliday, EG, Nalls, M, Parolo, S, Bione, S, Giese, AK, Boncoraglio, GB, Maguire, JM, Müller-Nurasyid, M, Gieger, C, Meschia, JF, Rosand, J, Rolfs, A, Kittner, SJ, Mitchell, BD, O'Connell, JR, Cheng, YC |
| Rok vydání: |
2015 |
| Předmět: |
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| Popis: |
© 2015 European Academy of Neurology. Background and purpose: Although the genetic contribution to stroke risk is well known, it remains unclear if young-onset stroke has a stronger genetic contribution than old-onset stroke. This study aims to compare the heritability of ischaemic stroke risk between young and old, using common genetic variants from whole-genome array data in population-based samples. Methods: This analysis included 4050 ischaemic stroke cases and 5765 controls from six study populations of European ancestry; 47% of cases were young-onset stroke (age < 55 years). To quantify the heritability for stroke risk in these unrelated individuals, the pairwise genetic relatedness was estimated between individuals based on their whole-genome array data using a mixed linear model. Heritability was estimated separately for young-onset stroke and old-onset stroke (age ≥ 55 years). Results: Heritabilities for young-onset stroke and old-onset stroke were estimated at 42% (±8%, P < 0.001) and 34% (±10%, P < 0.001), respectively. Conclusions: Our data suggest that the genetic contribution to the risk of stroke may be higher in young-onset ischaemic stroke, although the difference was not statistically significant. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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