| Autor: |
Granell, Raquel, Curtin, John A., Haider, Sadia, Kitaba, Negusse Tadesse, Mathie, Sara A., Gregory, Lisa G., Yates, Laura L., Tutino, Mauro, Hankinson, Jenny, Perretti, Mauro, Vonk, Judith M., Arshad, Hasan S., Cullinan, Paul, Fontanella, Sara, Roberts, Graham C., Koppelman, Gerard H., Simpson, Angela, Turner, Steve W, Murray, Clare S., Lloyd, Clare M., Holloway, John W., Custovic, Adnan |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| ISSN: |
7526-0654 |
| Popis: |
Background: many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of 'doctor-diagnosed asthma', thereby diluting genetic signals by not considering asthma heterogeneity. The objective of our study was to identify genetic associates of childhood wheezing phenotypes.Methods: we conducted a novel multivariate GWAS meta-analysis of wheezing phenotypes jointly derived using unbiased analysis of data collected from birth to 18 years in 9,568 individuals from five UK birth-cohorts.Results: 44 independent SNPs were associated with early-onset persistent, 25 with preschool remitting, 33 with mid-childhood remitting and 32 with late-onset wheeze. We identified a novel locus on chr9q21.13 (close to annexin 1 (ANXA1), pConclusions: targeting this pathway in persistent disease may represent an exciting therapeutic prospect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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