| Autor: |
Clerick, Sander, Libbrecht, Wannes, van den Berg, Otto, De Canck, Els, Van Der Voort, Pascal |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
DZA meeting, Abstracts |
| Popis: |
Controlled drug release gained a sharply increasing interest over recent years. Multiple materials have been screened as possible drug carriers, ranging from biodegradable polymers to hydroxyapatite[1]. Periodic Mesoporous Organosilicas are valuable alternatives as they possess a high chemical and thermal stability combined with a biocompatible nature[2]. Furthermore, their large internal surface area permits a high drug loading. Careful selection of the organic ‘bridged’ functionality allows a controlled release with respect to external stimuli, such as pH or temperature, of the drugs which are adsorbed via weak and reversible interactions, e.g. H-bonding and hydrophobic-phobic interaction[3]. In this contribution a novel malonamide (MA-PMO) and a methyl-malonamide PMO (mMA-PMO) bearing a high amount of H-bond donors and acceptors is developed and thoroughly characterised. Subsequently, these hybrid materials are evaluated in the controlled drug release of Ibuprofen. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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