The influence of Shc proteins and high-fat diet on energy metabolism of mice
| Autor: | Baldassini, WA, Ramsey, JJ, Hagopian, K, Lanna, DPD |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Biochemistry & Molecular Biology Knockout 1.1 Normal biological development and functioning glycolysis Inbred C57BL Weight Gain bioenergetics beta-oxidation Oral and gastrointestinal Diet mitochondria Mice High-Fat Shc Signaling Adaptor Proteins Underpinning research energy expenditure Animals Obesity Biochemistry and Cell Biology Energy Metabolism Digestive Diseases Metabolic and endocrine Nutrition |
| Zdroj: | Cell biochemistry and function, vol 35, iss 8 |
| Popis: | The purpose of this study was to determine if Shc proteins influence the metabolic response to acute (7days) feeding of a high-fat diet (HFD). To this end, whole animal energy expenditure (EE) and substrate oxidation were measured in the Shc knockout (ShcKO) and wild-type (WT) mice fed a control or HFD. The activities of enzymes of glycolysis, the citric acid cycle, electron transport chain (ETC), and β-oxidation were also investigated in liver and skeletal muscle of ShcKO and WT animals. The study showed that ShcKO increases (P |
| Databáze: | OpenAIRE |
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