Akt-dependent phosphorylation of hepatic Foxo1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity

Autor: Farese, Robert, Sajan, MP, Acevedo-Duncan, ME, Standaert, ML, Ivey, RA, Lee, M, Farese, RV
Jazyk: angličtina
Rok vydání: 2014
Zdroj: Farese, Robert; Sajan, MP; Acevedo-Duncan, ME; Standaert, ML; Ivey, RA; Lee, M; et al.(2014). Akt-dependent phosphorylation of hepatic Foxo1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5q57x1g7
Popis: Initiating mechanisms that impair gluconeogenic enzymes and spare lipogenic enzymes in diet-induced obesity (DIO) are obscure. Here, we examined insulin signaling to Akt and atypical protein kinase C (aPKC) in liver and muscle and hepatic enzyme expression
Databáze: OpenAIRE