A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors
| Autor: | Ware, LB, Landeck, M, Koyama, T, Zhao, Z, Singer, J, Kern, R, Neidlinger, N, Nguyen, J, Johnson, E, Janz, DR, Bernard, GR, Lee, JW, Matthay, MA, California Transplant Donor Network |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Brain Death Tissue and Organ Procurement California Transplant Donor Network Clinical Trials and Supportive Activities Pulmonary Edema Medical and Health Sciences Oxygen Consumption Double-Blind Method Clinical Research lung transplantation Humans Albuterol Prospective Studies Lung clinical trials Nebulizers and Vaporizers Evaluation of treatments and therapeutic interventions Prognosis Tissue Donors Asthma Bronchodilator Agents Case-Control Studies 6.1 Pharmaceuticals Respiratory Female Surgery donor management Follow-Up Studies |
| Zdroj: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol 14, iss 3 |
| Popis: | Donor lung utilization rates are persistently low primarily due to donor lung dysfunction. We hypothesized that a treatment that enhances the resolution of pulmonary edema by stimulating the rate of alveolar fluid clearance would improve donor oxygenation and increase donor lung utilization. We conducted a randomized, blinded, placebo-controlled trial of aerosolized albuterol (5mg q4h) versus saline placebo during active donor management in 506 organ donors.The primary outcome was change in oxygenation arterial partial pressure of oxygen/fraction of inspired oxygen [PaO2/FiO2] from enrollment to organ procurement.The albuterol (n¼260) and placebo (n¼246)groups were well matched for age, gender, ethnicity,smoking, and cause of brain death. The change in PaO2/FiO2 from enrollment to organ procurement did not differ between treatment groups (p¼0.54) nor did donor lung utilization (albuterol 29% vs. placebo 32%,p¼0.44). Donors in the albuterol versus placebo groups were more likely to have the study drug dose reduced (13% vs. 1%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|