Traffic-related air pollution, biomarkers of metabolic dysfunction, oxidative stress, and CC16 in children
Autor: | Zhang, Amy L, Balmes, John R, Lutzker, Liza, Mann, Jennifer K, Margolis, Helene G, Tyner, Tim, Holland, Nina, Noth, Elizabeth M, Lurmann, Fred, Hammond, S Katharine, Holm, Stephanie M |
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Rok vydání: | 2022 |
Předmět: |
Pediatric Research Initiative
HDL Epidemiology Nitrogen Dioxide Low-SES Populations Medical and Health Sciences Clinical Research Air Pollution Humans Uteroglobin 2.1 Biological and endogenous factors 2.2 Factors relating to the physical environment Climate-Related Exposures and Conditions Polycyclic Aromatic Hydrocarbons Aetiology Child Lung Vehicle Emissions Glycated Hemoglobin Pediatric Air Pollutants Early Life Childhood Exposure Traffic-related Air Pollution Prevention Environmental Exposure Oxidative Stress Cross-Sectional Studies Cholesterol Metabolic Dysregulation Chemical Sciences Particulate Matter Biomarkers Environmental Sciences |
Zdroj: | Journal of exposure science & environmental epidemiology, vol 32, iss 4 |
Popis: | BackgroundPrevious research has revealed links between air pollution exposure and metabolic syndrome in adults; however, these associations are less explored in children.ObjectiveThis study aims to investigate the association between traffic-related air pollutants (TRAP) and biomarkers of metabolic dysregulation, oxidative stress, and lung epithelial damage in children.MethodsWe conducted cross-sectional analyses in a sample of predominantly Latinx, low-income children (n = 218) to examine associations between air pollutants (nitrogen dioxide (NO2), nitrogen oxides (NOx), elemental carbon, polycyclic aromatic hydrocarbons, carbon monoxide (CO), fine particulates (PM2.5)) and biomarkers of metabolic function (high-density lipoprotein (HDL), hemoglobin A1c (HbA1c), oxidative stress (8-isoprostane), and lung epithelial damage (club cell protein 16 (CC16)).ResultsHDL cholesterol showed an inverse association with NO2 and NOx, with the strongest relationship between HDL and 3-month exposure to NO2 (-15.4 mg/dL per IQR increase in 3-month NO2, 95% CI = -27.4, -3.4). 8-isoprostane showed a consistent pattern of increasing values with 1-day and 1-week exposure across all pollutants. Non-significant increases in % HbA1c were found during 1-month time frames and decreasing CC16 in 3-month exposure time frames.ConclusionOur results suggest that TRAP is significantly associated with decreased HDL cholesterol in longer-term time frames and elevated 8-isoprostane in shorter-term time frames. TRAP could have the potential to influence lifelong metabolic patterns, through metabolic effects in childhood. |
Databáze: | OpenAIRE |
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