| Autor: |
Steel, A, Chiew, M, Jezzard, P, Voets, NL, Plaha, P, Thomas, MA, Stagg, CJ, Emir, UE |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Zdroj: |
Steel, A; Chiew, M; Jezzard, P; Voets, NL; Plaha, P; Thomas, MA; et al.(2018). Metabolite-cycled density-weighted concentric rings k-space trajectory (DW-CRT) enables high-resolution 1 H magnetic resonance spectroscopic imaging at 3-Tesla. Scientific Reports, 8(1). doi: 10.1038/s41598-018-26096-y. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4t012794 |
| DOI: |
10.1038/s41598-018-26096-y. |
| Popis: |
© 2018 The Author(s). Magnetic resonance spectroscopic imaging (MRSI) is a promising technique in both experimental and clinical settings. However, to date, MRSI has been hampered by prohibitively long acquisition times and artifacts caused by subject motion and hardware-related frequency drift. In the present study, we demonstrate that density weighted concentric ring trajectory (DW-CRT) k-space sampling in combination with semi-LASER excitation and metabolite-cycling enables high-resolution MRSI data to be rapidly acquired at 3 Tesla. Single-slice full-intensity MRSI data (short echo time (TE) semi-LASER TE = 32 ms) were acquired from 6 healthy volunteers with an in-plane resolution of 5 × 5 mm in 13 min 30 sec using this approach. Using LCModel analysis, we found that the acquired spectra allowed for the mapping of total N-acetylaspartate (median Cramer-Rao Lower Bound [CRLB] = 3%), glutamate+glutamine (8%), and glutathione (13%). In addition, we demonstrate potential clinical utility of this technique by optimizing the TE to detect 2-hydroxyglutarate (long TE semi-LASER, TE = 110 ms), to produce relevant high-resolution metabolite maps of grade III IDH-mutant oligodendroglioma in a single patient. This study demonstrates the potential utility of MRSI in the clinical setting at 3 Tesla. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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