| Autor: |
Yu, Yanhui Peter |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Yu, Yanhui Peter. (2015). Maladaptive Synaptogenesis induced by interaction of voltage gated calcium channel subunit alpha2delta-1 and thrombospondin-4 represents a new mechanism underlying neuropathic pain processing in nerve injury models. UC Irvine: Pharmacology and Toxicology. Retrieved from: http://www.escholarship.org/uc/item/2j94z08x |
| Popis: |
The molecular basis of neuropathic pain is poorly understood. We have previously shown that nerve injury induces increased production of thrombospondin-4 and voltage-gated calcium channel subunit α2δ-1 and that these proteins play a critical role in mediating behavioral hypersensitivity in animal models. However, the mechanism of action has not been elucidated. I use immunohistochemical staining in nerve injured animal model spinal cords to show that interaction of thrombospondin-4 with α2δ-1 promote excitatory synaptogenesis. Furthermore, I use immunocytochemistry staining in spinal cord and dorsal root ganglia neuron co-culture to show that thrombospondins-4/α2δ-1 interaction mediated synaptogenesis depends on pre-synaptic T-type voltage-gated calcium channel function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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