Global absence and targeting of protective immune states in severe COVID-19
Autor: | Combes, Alexis J, Courau, Tristan, Kuhn, Nicholas F, Hu, Kenneth H, Ray, Arja, Chen, William S, Chew, Nayvin W, Cleary, Simon J, Kushnoor, Divyashree, Reeder, Gabriella C, Shen, Alan, Tsui, Jessica, Hiam-Galvez, Kamir J, Muñoz-Sandoval, Priscila, Zhu, Wandi S, Lee, David S, Sun, Yang, You, Ran, Magnen, Mélia, Rodriguez, Lauren, Im, KW, Serwas, Nina K, Leligdowicz, Aleksandra, Zamecnik, Colin R, Loudermilk, Rita P, Wilson, Michael R, Ye, Chun J, Fragiadakis, Gabriela K, Looney, Mark R, Chan, Vincent, Ward, Alyssa, Carrillo, Sidney, UCSF COMET Consortium, Matthay, Michael, Erle, David J, Woodruff, Prescott G, Langelier, Charles, Kangelaris, Kirsten, Hendrickson, Carolyn M, Calfee, Carolyn, Rao, Arjun Arkal, Krummel, Matthew F |
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Rok vydání: | 2021 |
Předmět: |
Male
Neutrophils IgG General Science & Technology 1.1 Normal biological development and functioning Antibodies Interferon alpha-beta Vaccine Related Protein Domains Underpinning research Biodefense Receptors Genetics Humans 2.1 Biological and endogenous factors Viral Aetiology Lung Base Sequence SARS-CoV-2 Prevention Inflammatory and immune system COVID-19 Viral Load UCSF COMET Consortium Infectious Diseases Emerging Infectious Diseases Good Health and Well Being Immunoglobulin G Antibody Formation Female Interferons Single-Cell Analysis Receptor |
Zdroj: | Nature, vol 591, iss 7848 |
Popis: | Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has pleiotropic and systemic effects in some individuals1-3, many others experience milder symptoms. Here, to gain a more comprehensive understanding of the distinction between severe and mild phenotypes in the pathology of coronavirus disease 2019 (COVID-19) and its origins, we performed a whole-blood-preserving single-cell analysis protocol to integrate contributions from all major immune cell types of the blood-including neutrophils, monocytes, platelets, lymphocytes and the contents of the serum. Patients with mild COVID-19 exhibit a coordinated pattern of expression of interferon-stimulated genes (ISGs)3 across every cell population, whereas these ISG-expressing cells are systemically absent in patients with severe disease. Paradoxically, individuals with severe COVID-19 produce very high titres of anti-SARS-CoV-2 antibodies and have a lower viral load compared to individuals with mild disease. Examination of the serum from patients with severe COVID-19 shows that these patients uniquely produce antibodies that functionally block the production of the ISG-expressing cells associated with mild disease, by activating conserved signalling circuits that dampen cellular responses to interferons. Overzealous antibody responses pit the immune system against itself in many patients with COVID-19, and perhaps also in individuals with other viral infections. Our findings reveal potential targets for immunotherapies in patients with severe COVID-19 to re-engage viral defence. |
Databáze: | OpenAIRE |
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