Dietary factors, gut microbiota, and serum trimethylamine-N-oxide associated with cardiovascular disease in the Hispanic Community Health Study/Study of Latinos

Autor: Mei, Zhendong, Chen, Guo-Chong, Wang, Zheng, Usyk, Mykhaylo, Yu, Bing, Baeza, Yoshiki Vazquez, Humphrey, Greg, Benitez, Rodolfo Salido, Li, Jun, Williams-Nguyen, Jessica S, Daviglus, Martha L, Hou, Lifang, Cai, Jianwen, Zheng, Yan, Knight, Rob, Burk, Robert D, Boerwinkle, Eric, Kaplan, Robert C, Qi, Qibin
Rok vydání: 2021
Předmět:
Zdroj: The American journal of clinical nutrition, vol 113, iss 6
Popis: BackgroundTrimethylamine-N-oxide (TMAO), a diet-derived and gut microbiota-related metabolite, is associated with cardiovascular disease (CVD). However, major dietary determinants and specific gut bacterial taxa related to TMAO remain to be identified in humans.ObjectivesWe aimed to identify dietary and gut microbial factors associated with circulating TMAO.MethodsThis cross-sectional study included 3972 participants (57.3% women) aged 18-74 y from the Hispanic Community Health Study/Study of Latinos in the United States. Dietary information was collected by 24-h dietary recalls at baseline interview (2008-2011), and baseline serum TMAO and its precursors were measured by an untargeted approach. Gut microbiome was profiled by shotgun metagenomic sequencing in a subset of participants (n=626) during a follow-up visit (2016-2018). Logistic and linear regression were used to examine associations of inverse-normalized metabolites with prevalent CVD, dietary intake, and bacterial species, respectively, after adjustment for sociodemographic, behavioral, and clinical factors.ResultsTMAO was positively associated with prevalent CVD (case number=279; OR = 1.34; 95% CI: 1.17, 1.54, per 1-SD). Fish (P=1.26×10-17), red meat (P=3.33×10-16), and egg (P=3.89×10-5) intakes were top dietary factors positively associated with TMAO. We identified 9 gut bacterial species significantly associated with TMAO (false discovery rate
Databáze: OpenAIRE