Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice

Autor: McKerrow, James, Leung, Jacqueline, McCune, Joseph, Broadhurst, MJ, Leung, JM, Lim, KC, Girgis, NM, Gundra, UM, Fallon, PG, Premenko-Lanier, M, McKerrow, JH, McCune, JM, Loke, P
Jazyk: angličtina
Rok vydání: 2012
Zdroj: McKerrow, James; Leung, Jacqueline; McCune, Joseph; Broadhurst, MJ; Leung, JM; Lim, KC; et al.(2012). Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0zt3x35b
Popis: Although the vitamin A metabolite retinoic acid (RA) plays a critical role in immune function, RA synthesis during infection is poorly understood. Here, we show that retinal dehydrogenases (Raldh), required for the synthesis of RA, are induced during a ret
Databáze: OpenAIRE