| Autor: |
Bezman, NA, Kim, CC, Sun, JC, Min-Oo, G, Hendricks, DW, Kamimura, Y, Best, JA, Goldrath, AW, Lanier, LL, Gautier, EL, Jakubzick, C, Randolph, GJ, Best, AJ, Knell, J, Miller, J, Brown, B, Merad, M, Jojic, V, Koller, D, Cohen, N, Brennan, P, Brenner, M, Shay, T, Regev, A, Fletcher, A, Elpek, K, Bellemare-Pelletier, A, Malhotra, D, Turley, S, Jianu, R, Laidlaw, D, Collins, JJ, Narayan, K, Sylvia, K, Kang, J, Gazit, R, Rossi, DJ, Kim, F, Rao, TN, Wagers, A, Shinton, SA, Hardy, RR, Monach, P, Heng, T, Kreslavsky, T, Painter, M, Ericson, J, Davis, S, Mathis, D, Benoist, C |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Zdroj: |
Bezman, NA; Kim, CC; Sun, JC; Min-Oo, G; Hendricks, DW; Kamimura, Y; et al.(2012). Molecular definition of the identity and activation of natural killer cells. Nature Immunology, 13(10), 1000-1008. doi: 10.1038/ni.2395. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1jv0g51v |
| Popis: |
Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8 + T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many encoding molecules with unknown functions. Resting NK cells demonstrate a 'preprimed' state compared with naive T cells, which allows NK cells to respond more rapidly to viral infection. Collectively, our data provide a global context for known and previously unknown molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states. © 2012 Nature America, Inc. All rights reserved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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