| Autor: |
Toedebusch, Ryan G, Wei, Ning-Wei, Simafranca, Kulani T, Furth-Jacobus, Jennie A, Brust-Mascher, Ingrid, Stewart, Susan L, Dickinson, Peter J, Woolard, Kevin D, Li, Chai-Fei, Vernau, Karen M, Meyers, Frederick J, Toedebusch, Christine M |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Veterinary sciences, vol 10, iss 6 |
| Popis: |
The goal of this study was to define the glioma-associated microglia/macrophage (GAM) response and associated molecular landscape in canine oligodendrogliomas. Here, we quantified the intratumoral GAM density of low- and high-grade oligodendrogliomas compared to that of a normal brain, as well as the intratumoral concentration of several known GAM-derived pro-tumorigenic molecules in high-grade oligodendrogliomas compared to that in a normal brain. Our analysis demonstrated marked intra- and intertumoral heterogeneity of GAM infiltration. Correspondingly, we observed significant variability in the intratumoral concentrations of several GAM-associated molecules, unlike what we previously observed in high-grade astrocytomas. However, high-grade oligodendroglioma tumor homogenates (n = 6) exhibited an increase in the pro-tumorigenic molecules hepatocyte growth factor receptor (HGFR) and vascular endothelial growth factor (VEGF), as we observed in high-grade astrocytomas. Moreover, neoplastic oligodendrocytes displayed robust expression of GAL-3, a chimeric galectin implicated in driving immunosuppression in human glioblastoma. While this work identifies shared putative therapeutic targets across canine glioma subtypes (HGFR, GAL-3), it highlights several key differences in the immune landscape. Therefore, a continued effort to develop a comprehensive understanding of the immune microenvironment within each subtype is necessary to inform therapeutic strategies going forward. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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