Weight Trajectory over 20 Years and Likelihood of Mild Cognitive Impairment or Dementia Among Older Women
| Autor: | LeBlanc, Erin S, Rizzo, Joanne H, Pedula, Kathryn L, Yaffe, Kristine, Ensrud, Kristine E, Cauley, Jane, Cawthon, Peggy M, Cummings, Steven, Hillier, Teresa A, Study of Osteoporotic Fractures (SOF) Research Group |
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| Rok vydání: | 2017 |
| Předmět: |
Aging
Clinical Trials and Supportive Activities Neuropsychological Tests Neurodegenerative Alzheimer's Disease Medical and Health Sciences Cohort Studies cognitive dysfunction Clinical Research Weight Loss 80 and over Acquired Cognitive Impairment Humans Aged weight trajectory Body Weight Rehabilitation Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) United States Brain Disorders Logistic Models Mental Health Study of Osteoporotic Fractures (SOF) Research Group Geriatrics Neurological Dementia Female |
| Zdroj: | Journal of the American Geriatrics Society, vol 65, iss 3 |
| Popis: | ObjectivesThe association between weight change and cognition is controversial. We examined the association between 20-year weight change and cognitive function in late life.DesignCohort study.SettingStudy of Osteoporotic Fractures (SOF).ParticipantsOne thousand two hundred eighty-nine older, community-dwelling women (mean baseline age 68 (65-81) and 88 (82-102) at cognitive testing).MeasurementsStudy of Osteoporotic Fractures participants had body weight measured repeatedly over 20 years (mean 8 weights). Adjudicated cognitive status was classified as normal (n = 775) or mild cognitive impairment (MCI)/dementia (n = 514) at Year 20. Logistic models were used to evaluate whether absolute weight change, rate of weight loss per year, presence of abrupt, unrecovered weight loss, and weight variability were associated with MCI or dementia.ResultsWomen with greater rate of weight loss over 20 years had increased chance of developing MCI or dementia. In age/education/clinic-adjusted "base" models, each 0.5 kg/yr decrease resulted in 30% increased odds of MCI/dementia (OR = 1.30 [95% CI: 1.14, 1.49]). After adjustment for age, education, clinic, depression, and walking speed, there was 17% (OR = 1.17 [95% CI: 1.02, 1.35]) increased odds of MCI/dementia for each 0.5 kg/yr decrease in weight. In base models, variability in weight was significant. Each 1% average deviation from each woman's predicted weight curve was associated with 11% increased odds of MCI/dementia (OR = 1.11 [95% CI: 1.04, 1.18]). The estimate was attenuated after full adjustment (OR = 1.06 [95% CI: 0.99, 1.14]). The presence of an abrupt weight decline was not associated with MCI/dementia.ConclusionsRate of weight loss over 20 years was associated with development of MCI or dementia in women surviving past 80 years, suggesting that nutritional status, social-environmental factors, and/or adipose tissue function and structure may affect cognitive function with aging. |
| Databáze: | OpenAIRE |
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