| Autor: |
Matheny, ES, Hanna, NM, Jung, WG, Chen, Z, Wilder-Smith, P, Mina-Araghi, R, Brenner, M |
| Jazyk: |
angličtina |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Matheny, ES; Hanna, NM; Jung, WG; Chen, Z; Wilder-Smith, P; Mina-Araghi, R; et al.(2004). Optical coherence tomography of malignancy in hamster cheek pouches. Journal of Biomedical Optics, 9(5), 978-981. doi: 10.1117/1.1783897. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2mp4k0tm |
| Popis: |
Optical coherence tomography (OCT)/optical Doppler tomography (ODT) provides real-time in vivo high-resolution (10-μm) imaging of tissues and real-time spatially resolved blood flow in microvasculature. Hamster cheek pouches with induced dysplasia and malignancies were imaged with OCT/ODT to assess the potential for application to airway malignancy. In 22 Golden Syrian hamsters, 0.5% 9,10-dimethyl-1,2-benzanthracene induces carcinogenesis over 10 weeks in right side cheek pouches; the left side three served as controls. The cheek pouches are imaged in vivo prior to sacrifice, and in vitro after excision, using a prototype 1310-nm broadband superluminescent diode based OCT/ODT device. Images are compared to standard histopathology. OCT imaging offers good resolution of the hamster cheek pouches to depths of 1 to 3 mm and paralleled histologic images. The feasibility of high-resolution functional imaging is demonstrated in this hamster cheek pouch tumor model. ODT accurately detects vascular change associated with carcinogenesis. © 2004 Society of Photo-Optical Instrumentation Engineers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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