MRI Features May Predict Molecular Features of Glioblastoma in Isocitrate Dehydrogenase Wild-Type Lower-Grade Gliomas
| Autor: | Park, CJ, Han, K, Kim, H, Ahn, SS, Choi, D, Park, YW, Chang, JH, Kim, SH, Cha, S, Lee, S-K |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Brain Neoplasms Clinical Sciences Neurosciences Middle Aged Magnetic Resonance Imaging Isocitrate Dehydrogenase Brain Disorders Machine Learning Brain Cancer Nuclear Medicine & Medical Imaging Computer-Assisted Rare Diseases Clinical Research Mutation Humans Female Glioblastoma Image Interpretation Retrospective Studies Cancer |
| Zdroj: | AJNR. American journal of neuroradiology, vol 42, iss 3 |
| Popis: | Background and purposeIsocitrate dehydrogenase (IDH) wild-type lower-grade gliomas (histologic grades II and III) with epidermal growth factor receptor (EGFR) amplification or telomerase reverse transcriptase (TERT) promoter mutation are reported to behave similar to glioblastoma. We aimed to evaluate whether MR imaging features could identify a subset of IDH wild-type lower-grade gliomas that carry molecular features of glioblastoma.Materials and methodsIn this multi-institutional retrospective study, pathologically confirmed IDH wild-type lower-grade gliomas from 2 tertiary institutions and The Cancer Genome Atlas constituted the training set (institution 1 and The Cancer Genome Atlas, 64 patients) and the independent test set (institution 2, 57 patients). Preoperative MRIs were analyzed using the Visually AcceSAble Rembrandt Images and radiomics. The molecular glioblastoma status was determined on the basis of the presence of EGFR amplification and TERT promoter mutation. Molecular glioblastoma was present in 73.4% and 56.1% in the training and test sets, respectively. Models using clinical, Visually AcceSAble Rembrandt Images, and radiomic features were built to predict the molecular glioblastoma status in the training set; then they were validated in the test set.ResultsIn the test set, a model using both Visually AcceSAble Rembrandt Images and radiomic features showed superior predictive performance (area under the curve = 0.854) than that with only clinical features or Visually AcceSAble Rembrandt Images (areas under the curve = 0.514 and 0.648, respectively; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|