Nanoparticle-based Cell Trackers for Biomedical Applications

Autor: Ni, Jen-Shyang, Li, Yaxi, Yue, Wentong, Liu, Bin, Li, Kai
Rok vydání: 2020
Předmět:
Urologic Diseases
Male
Aging
aggregation-induced emission
Photothermal Therapy
diagnosis
Oncology and Carcinogenesis
Contrast Media
Ultrafiltration
Bioengineering
Theranostic Nanomedicine
Nanodiamonds
Photoacoustic Techniques
Clinical Research
Quantum Dots
Animals
Humans
Nanotechnology
bioimaging
Precision Medicine
Cancer
therapy
screening and diagnosis
Chromatography
Gel
Tumor
semiconducting polymer
liquid biopsy
Prevention
Prostate Cancer
Optical Imaging
Prostatic Neoplasms
Prognosis
Magnetic Resonance Imaging
4.1 Discovery and preclinical testing of markers and technologies
Detection
Good Health and Well Being
Photochemotherapy
cell tracking
Molecular Probes
Nanoparticles
biomarker
Biomedical Imaging
extracellular vesicles
Ultracentrifugation
Biomarkers
4.2 Evaluation of markers and technologies
Zdroj: Theranostics, vol 10, iss 4
Popis: The continuous or real-time tracking of biological processes using biocompatible contrast agents over a certain period of time is vital for precise diagnosis and treatment, such as monitoring tissue regeneration after stem cell transplantation, understanding the genesis, development, invasion and metastasis of cancer and so on. The rationally designed nanoparticles, including aggregation-induced emission (AIE) dots, inorganic quantum dots (QDs), nanodiamonds, superparamagnetic iron oxide nanoparticles (SPIONs), and semiconducting polymer nanoparticles (SPNs), have been explored to meet this urgent need. In this review, the development and application of these nanoparticle-based cell trackers for a variety of imaging technologies, including fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, magnetic particle imaging, positron emission tomography and single photon emission computing tomography are discussed in detail. Moreover, the further therapeutic treatments using multi-functional trackers endowed with photodynamic and photothermal modalities are also introduced to provide a comprehensive perspective in this promising research field.
Databáze: OpenAIRE
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