Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso-heptadecanoic Acid Are Inversely Associated With Liver Fat in Children
| Autor: | Sawh, Mary Catherine, Wallace, Martina, Shapiro, Emma, Goyal, Nidhi P, Newton, Kimberly P, Yu, Elizabeth L, Bross, Craig, Durelle, Janis, Knott, Cynthia, Gangoiti, Jon A, Barshop, Bruce A, Gengatharan, Jivani M, Meurs, Noah, Schlein, Alexandra, Middleton, Michael S, Sirlin, Claude B, Metallo, Christian M, Schwimmer, Jeffrey B |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatric
milk obesity Adolescent Gastroenterology & Hepatology Prevention Liver Disease Fatty Acids Chronic Liver Disease and Cirrhosis Magnetic Resonance Imaging Medical and Health Sciences Oral and gastrointestinal Cross-Sectional Studies nutrition Liver Non-alcoholic Fatty Liver Disease Humans nonalcoholic steatohepatitis Child Digestive Diseases Metabolic and endocrine |
| Zdroj: | Journal of pediatric gastroenterology and nutrition, vol 72, iss 4 |
| Popis: | ObjectivesWe sought to evaluate the relevance of pediatric dairy fat recommendations for children at risk for nonalcoholic fatty liver disease (NAFLD) by studying the association between dairy fat intake and the amount of liver fat. The effects of dairy fat may be mediated by odd chain fatty acids (OCFA), such as pentadecanoic acid (C15:0), and monomethyl branched chain fatty acids (BCFA), such as iso-heptadecanoic acid (iso-C17:0). Therefore, we also evaluated the association between plasma levels of OCFA and BCFA with the amount of liver fat.MethodsObservational, cross-sectional, community-based sample of 237 children ages 8 to 17. Dairy fat intake was assessed by 3 24-hour dietary recalls. Plasma fatty acids were measured by gas chromatography-mass spectrometry. Main outcome was hepatic steatosis measured by whole liver magnetic resonance imaging proton density fat fraction (MRI-PDFF).ResultsMedian dairy fat intake was 10.6 grams/day (range 0.0--44.5 g/day). Median liver MRI-PDFF was 4.5% (range 0.9%-45.1%). Dairy fat intake was inversely correlated with liver MRI-PDFF (r = -0.162; P = .012). In multivariable log linear regression, plasma C15:0 and iso-C17:0 were inverse predictors of liver MRI-PDFF (B = -0.247, P = 0.048; and B = -0.234, P = 0.009).ConclusionsDairy fat intake, plasma C15:0, and plasma iso-C17:0 were inversely correlated with hepatic steatosis in children. These hypothesis-generating findings should be tested through clinical trials to better inform dietary guidelines. |
| Databáze: | OpenAIRE |
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